Does NMN have any known side effects?Updated 4 days ago

The first human safety trial of NMN in humans was published in 2019 and showed that a single dose of up to 500mg was tolerable.

NMN has been proven safe in high dosages up to 1.2g a day in human clinical studies. Furthermore, multiple health benefits have been demonstrated in humans as well. A study in prediabetic, postmenopausal, obese or overweight women showed that after 10 weeks of NMN supplementation, the volunteers had increased insulin sensitivity. Same study showed that NMN supplementation was able to stimulate the collagen production pathway, suggesting the compound's role in healthy aging (and appearance of skin).

A study in elderly men over 65 showed that NMN supplementation protects against age-related muscle loss. Another study in healthy, adult volunteers of both sexes confirmed that NMN increases endurance, cardiovascular fitness and aerobic capacity in amateur runners.